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Transcriptional suppression of ribosomal DNA with phase separation

The nucleolus is a nuclear body with multiphase liquid droplets for ribosomal RNA (rRNA) transcription. How rRNA transcription is regulated in the droplets remains unclear. Here, using single-molecule tracking of RNA polymerase I (Pol I) and chromatin-bound upstream binding factor (UBF), we reveal s...

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Detalles Bibliográficos
Autores principales: Ide, Satoru, Imai, Ryosuke, Ochi, Hiroko, Maeshima, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556839/
https://www.ncbi.nlm.nih.gov/pubmed/33055158
http://dx.doi.org/10.1126/sciadv.abb5953