Cargando…

Transcriptional suppression of ribosomal DNA with phase separation

The nucleolus is a nuclear body with multiphase liquid droplets for ribosomal RNA (rRNA) transcription. How rRNA transcription is regulated in the droplets remains unclear. Here, using single-molecule tracking of RNA polymerase I (Pol I) and chromatin-bound upstream binding factor (UBF), we reveal s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ide, Satoru, Imai, Ryosuke, Ochi, Hiroko, Maeshima, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556839/ https://www.ncbi.nlm.nih.gov/pubmed/33055158 http://dx.doi.org/10.1126/sciadv.abb5953

Ejemplares similares

Phase separation in gene transcription control: Phase separation in gene transcription control
por: Li, Chengyu, et al.
Publicado: (2023)

Density imaging of heterochromatin in live cells using orientation-independent-DIC microscopy
por: Imai, Ryosuke, et al.
Publicado: (2017)

Spatial separation of ribosomes and DNA in Asgard archaeal cells
por: Avcı, Burak, et al.
Publicado: (2021)

Discontinuous transcription of ribosomal DNA in human cells
por: Smirnov, Evgeny, et al.
Publicado: (2020)

1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
por: Itoh, Yuji, et al.
Publicado: (2021)

Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats
por: Foss, Eric J., et al.
Publicado: (2019)

End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter
por: Ide, Satoru, et al.
Publicado: (2015)

Rtt109 Prevents Hyper-Amplification of Ribosomal RNA Genes through Histone Modification in Budding Yeast
por: Ide, Satoru, et al.
Publicado: (2013)

CRISPR-assisted transcription activation by phase-separation proteins
por: Liu, Jiaqi, et al.
Publicado: (2023)

Chromatin as dynamic 10-nm fibers
por: Maeshima, Kazuhiro, et al.
Publicado: (2014)

Transcriptional Mutagenesis Prevents Ribosomal DNA Deterioration: The Role of Duplications and Deletions
por: Colizzi, Enrico Sandro, et al.
Publicado: (2019)

Variability of Human rDNA and Transcription Activity of the Ribosomal Genes
por: Chmúrčiaková, Nikola, et al.
Publicado: (2022)

The Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis
por: Ponti, Donatella, et al.
Publicado: (2014)

Ribosomal DNA transcription in prefrontal pyramidal neurons is decreased in suicide
por: Krzyżanowska, Marta, et al.
Publicado: (2019)

Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441
por: Lin, Wen-Juan, et al.
Publicado: (2023)

Phase separation, transcriptional elongation control, and human diseases
por: Guo, Chenghao, et al.
Publicado: (2021)

Aonchotheca (Nematoda: Capillariidae) is validated as a separated genus from Capillaria by both mitochondrial and nuclear ribosomal DNA
por: Deng, Yuan-Ping, et al.
Publicado: (2022)

Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs
por: Ide, Satoru, et al.
Publicado: (2021)

rRNA transcription is integral to phase separation and maintenance of nucleolar structure
por: Dash, Soma, et al.
Publicado: (2023)

Compartmentalization of Telomeres through DNA-scaffolded Phase Separation
por: Jack, Amanda, et al.
Publicado: (2022)

Orientation-Independent-DIC imaging reveals that a transient rise in macromolecular crowding contributes to mitotic chromosome condensation
por: Iida, Shiori, et al.
Publicado: (2023)

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription
por: Andrews, William J., et al.
Publicado: (2021)

Suppression of Liquid‐Liquid Phase Separation and Aggregation of Antibodies by Modest Pressure Application
por: Fetahaj, Zamira, et al.
Publicado: (2022)

Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activity
por: Hu, Anpei, et al.
Publicado: (2023)

Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes
por: Firmino, Alexandre Augusto Pereira, et al.
Publicado: (2020)

Suppressed phase separation of mixed-halide perovskites confined in endotaxial matrices
por: Wang, Xi, et al.
Publicado: (2019)

Phase-separation antagonists potently inhibit transcription and broadly increase nucleosome density
por: Meduri, Rajyalakshmi, et al.
Publicado: (2022)

The rDNA is biomolecular condensate formed by polymer–polymer phase separation and is sequestered in the nucleolus by transcription and R-loops
por: Lawrimore, Josh, et al.
Publicado: (2021)

Ribosomal Protein S12 Hastens Nucleation of Co-Transcriptional Ribosome Assembly
por: Rodgers, Margaret L., et al.
Publicado: (2023)

The Physics of DNA Folding: Polymer Models and Phase-Separation
por: Esposito, Andrea, et al.
Publicado: (2022)

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors
por: Pessina, Fabio, et al.
Publicado: (2019)

Tandem trimer pyrrole–imidazole polyamide probes targeting 18 base pairs in human telomere sequences
por: Kawamoto, Yusuke, et al.
Publicado: (2015)

Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia
por: Krzyżanowska, Marta, et al.
Publicado: (2014)

Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription
por: Chen, Yangzi, et al.
Publicado: (2018)

Ribosomal DNA transcription is increased in the left nucleus accumbens of heroin-dependent males
por: Gos, Tomasz, et al.
Publicado: (2022)

Transcription of ribosomal genes can cause nondisjunction
por: Machín, Felix, et al.
Publicado: (2006)

Thymine DNA glycosylase mediates chromatin phase separation in a DNA methylation–dependent manner
por: McGregor, Lauren A., et al.
Publicado: (2023)

Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice
por: Schneider, Nils, et al.
Publicado: (2021)

Chemical ordering suppresses large-scale electronic phase separation in doped manganites
por: Zhu, Yinyan, et al.
Publicado: (2016)

Mutations in Ribosomal Proteins, RPL4 and RACK1, Suppress the Phenotype of a Thermospermine-Deficient Mutant of Arabidopsis thaliana
por: Kakehi, Jun-Ichi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_np4o8bh0uao34np20vcuju8901