Cryo-EM analysis of PIP(2) regulation in mammalian GIRK channels

G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP(2). Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP(2) concentration. We find that PIP(2) shifts the equilibriu...

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Detalles Bibliográficos
Autores principales: Niu, Yiming, Tao, Xiao, Touhara, Kouki K, MacKinnon, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556866/
https://www.ncbi.nlm.nih.gov/pubmed/32844743
http://dx.doi.org/10.7554/eLife.60552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556866/
https://www.ncbi.nlm.nih.gov/pubmed/32844743
http://dx.doi.org/10.7554/eLife.60552

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