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Cryo-EM analysis of PIP(2) regulation in mammalian GIRK channels

G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP(2). Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP(2) concentration. We find that PIP(2) shifts the equilibriu...

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Detalles Bibliográficos
Autores principales:	Niu, Yiming, Tao, Xiao, Touhara, Kouki K, MacKinnon, Roderick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556866/ https://www.ncbi.nlm.nih.gov/pubmed/32844743 http://dx.doi.org/10.7554/eLife.60552

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