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Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (Mus musculus), we demonstrated that rather than being driven by a Hh threshold, robust Gli3 tran...
Autores principales: | Elliott, Kelsey H, Chen, Xiaoting, Salomone, Joseph, Chaturvedi, Praneet, Schultz, Preston A, Balchand, Sai K, Servetas, Jeffrey D, Zuniga, Aimée, Zeller, Rolf, Gebelein, Brian, Weirauch, Matthew T, Peterson, Kevin A, Brugmann, Samantha A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556880/ https://www.ncbi.nlm.nih.gov/pubmed/33006313 http://dx.doi.org/10.7554/eLife.56450 |
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