Identification and in vivo characterization of a brain-penetrating nanobody

BACKGROUND: Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to the discovery of an anti-transferrin recepto...

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Detalles Bibliográficos
Autores principales: Wouters, Y, Jaspers, T, De Strooper, B, Dewilde, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556960/
https://www.ncbi.nlm.nih.gov/pubmed/33054787
http://dx.doi.org/10.1186/s12987-020-00226-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556960/
https://www.ncbi.nlm.nih.gov/pubmed/33054787
http://dx.doi.org/10.1186/s12987-020-00226-z

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