The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

BACKGROUND: Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases, such as frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). However, the role of...

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Detalles Bibliográficos
Autores principales: Lee, Shinrye, Kim, Seyeon, Kang, Ha-Young, Lim, Hye Ryeong, Kwon, Younghwi, Jo, Myungjin, Jeon, Yu-Mi, Kim, Sang Ryong, Kim, Kiyoung, Ha, Chang Man, Lee, Seongsoo, Kim, Hyung-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556969/
https://www.ncbi.nlm.nih.gov/pubmed/33054766
http://dx.doi.org/10.1186/s12974-020-01963-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556969/
https://www.ncbi.nlm.nih.gov/pubmed/33054766
http://dx.doi.org/10.1186/s12974-020-01963-6

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