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Poly(POG)n loaded with recombinant human bone morphogenetic protein-2 accelerates new bone formation in a critical-sized bone defect mouse model
BACKGROUND: Delivery of bone morphogenetic protein-2 (BMP-2) via animal-derived absorbable collagen materials is used for the treatment of large bone defects. However, the administration of bovine proteins to humans is associated with the risk of zoonotic complications. We therefore examined the eff...
Autores principales: | Tazawa, Ryo, Uchida, Kentaro, Minehara, Hiroaki, Matsuura, Terumasa, Kawamura, Tadashi, Sekiguchi, Hiroyuki, Muneshige, Kyoko, Inoue, Sho, Inoue, Gen, Takaso, Masashi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557057/ https://www.ncbi.nlm.nih.gov/pubmed/33054796 http://dx.doi.org/10.1186/s13018-020-01977-z |
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