XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation

Somatic mutations of the estrogen receptor 1 gene (ESR1) is an emerging mechanism of acquired resistance to endocrine therapy in hormonal breast cancers. Hotspot point mutations in the ligand- binding domain of estrogen receptor α (ER) and genomic rearrangements producing ESR1 fusion genes are the t...

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Detalles Bibliográficos
Autores principales: Barua, David, Abbasi, Benazir, Gupta, Ananya, Gupta, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557884/
https://www.ncbi.nlm.nih.gov/pubmed/33088967
http://dx.doi.org/10.1016/j.heliyon.2020.e05217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557884/
https://www.ncbi.nlm.nih.gov/pubmed/33088967
http://dx.doi.org/10.1016/j.heliyon.2020.e05217

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