Identification of Phomoxanthone A and B as Protein Tyrosine Phosphatase Inhibitors

[Image: see text] Phomoxanthone A and B (PXA and PXB) are xanthone dimers and isolated from the endophytic fungus Phomopsis sp. By254. The results demonstrated that PXB and PXA are noncompetitive inhibitors of SHP2 and PTP1B and competitive inhibitors of SHP1. Molecular docking studies showed that P...

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Detalles Bibliográficos
Autores principales: Yang, Runlei, Dong, Qian, Xu, Huibin, Gao, XueHui, Zhao, Ziyue, Qin, Jianchun, Chen, Chuan, Luo, Duqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557999/
https://www.ncbi.nlm.nih.gov/pubmed/33073119
http://dx.doi.org/10.1021/acsomega.0c03315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557999/
https://www.ncbi.nlm.nih.gov/pubmed/33073119
http://dx.doi.org/10.1021/acsomega.0c03315

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