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Identification of Phomoxanthone A and B as Protein Tyrosine Phosphatase Inhibitors
[Image: see text] Phomoxanthone A and B (PXA and PXB) are xanthone dimers and isolated from the endophytic fungus Phomopsis sp. By254. The results demonstrated that PXB and PXA are noncompetitive inhibitors of SHP2 and PTP1B and competitive inhibitors of SHP1. Molecular docking studies showed that P...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557999/ https://www.ncbi.nlm.nih.gov/pubmed/33073119 http://dx.doi.org/10.1021/acsomega.0c03315 |