Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats. We used pluronic P85 (P85) and tween 80, which have the potentia...

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Detalles Bibliográficos
Autores principales: Kwon, Mihwa, Lim, Dong Yu, Lee, Chul Haeng, Jeon, Ji-Hyeon, Choi, Min-Koo, Song, Im-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558015/
https://www.ncbi.nlm.nih.gov/pubmed/32957491
http://dx.doi.org/10.3390/pharmaceutics12090882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558015/
https://www.ncbi.nlm.nih.gov/pubmed/32957491
http://dx.doi.org/10.3390/pharmaceutics12090882

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