Simultaneous Quantification of Protein Binding Kinetics in Whole Cells with Surface Plasmon Resonance Imaging and Edge Deformation Tracking

Most drugs work by binding to receptors on the cell surface. Quantification of binding kinetics between drug and membrane protein is an essential step in drug discovery. Current methods for measuring binding kinetics involve extracting the membrane protein and labeling, and both have issues. Surface...

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Detalles Bibliográficos
Autores principales: Jing, Wenwen, Hunt, Ashley, Tao, Nongjian, Zhang, Fenni, Wang, Shaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558147/
https://www.ncbi.nlm.nih.gov/pubmed/32971834
http://dx.doi.org/10.3390/membranes10090247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558147/
https://www.ncbi.nlm.nih.gov/pubmed/32971834
http://dx.doi.org/10.3390/membranes10090247

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