Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis()

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Fanxun, Li, Shiliang, Yang, Guantian, Luo, Yating, Qi, Tiantian, Liang, Yingfan, Yang, Tingyuan, Zhang, Letian, Wang, Rui, Zhu, Lili, Li, Honglin, Xu, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558257/
https://www.ncbi.nlm.nih.gov/pubmed/33078092
http://dx.doi.org/10.1016/j.apsb.2020.10.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558257/
https://www.ncbi.nlm.nih.gov/pubmed/33078092
http://dx.doi.org/10.1016/j.apsb.2020.10.008

Ejemplares similares