A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats

An elevated level of endoplasmic reticulum (ER) stress is considered an aggravating factor for inflammatory bowel disease (IBD). To develop an ER-stress attenuator that is effective against colitis, 4-phenylbutyric acid (4-PBA), a chemical chaperone that alleviates ER stress, was conjugated with aci...

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Detalles Bibliográficos
Autores principales: Kim, Soojin, Lee, Seunghyun, Lee, Hanju, Ju, Sanghyun, Park, Sohee, Kwon, Doyoung, Yoo, Jin-Wook, Yoon, In-Soo, Min, Do Sik, Jung, Young-Suk, Jung, Yunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558321/
https://www.ncbi.nlm.nih.gov/pubmed/32899177
http://dx.doi.org/10.3390/pharmaceutics12090843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558321/
https://www.ncbi.nlm.nih.gov/pubmed/32899177
http://dx.doi.org/10.3390/pharmaceutics12090843

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