Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

Fibroblast-to-myofibroblast transition (FMT) is the primary inducer of cardiac fibrosis. ONO-1301, a synthetic prostacyclin agonist, reportedly promotes tissue fibrosis repair by enhancing anti-fibrotic cytokine production. We hypothesized that ONO-1301 attenuates pressure-overloaded cardiac fibrosi...

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Detalles Bibliográficos
Autores principales: Masada, Kenta, Miyagawa, Shigeru, Sakai, Yoshiki, Harada, Akima, Kanaya, Tomomitsu, Sawa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558785/
https://www.ncbi.nlm.nih.gov/pubmed/33102614
http://dx.doi.org/10.1016/j.omtm.2020.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558785/
https://www.ncbi.nlm.nih.gov/pubmed/33102614
http://dx.doi.org/10.1016/j.omtm.2020.09.005

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