Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology

Approximately 1%–2% of children with Down syndrome (DS) develop acute myeloid leukemia (AML) prior to age 5 years. AML in DS children (ML-DS) is characterized by the pathognomonic mutation in the gene encoding the essential hematopoietic transcription factor GATA1, resulting in N-terminally truncate...

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Detalles Bibliográficos
Autores principales: Barwe, Sonali P., Sidhu, Ishnoor, Kolb, E. Anders, Gopalakrishnapillai, Anilkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558799/
https://www.ncbi.nlm.nih.gov/pubmed/33102613
http://dx.doi.org/10.1016/j.omtm.2020.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558799/
https://www.ncbi.nlm.nih.gov/pubmed/33102613
http://dx.doi.org/10.1016/j.omtm.2020.09.007

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