Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1

Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of genes (FKS1 or FKS2) that encode the glucan s...

Descripción completa

Detalles Bibliográficos
Autores principales: Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558938/
https://www.ncbi.nlm.nih.gov/pubmed/32825653
http://dx.doi.org/10.3390/jof6030143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558938/
https://www.ncbi.nlm.nih.gov/pubmed/32825653
http://dx.doi.org/10.3390/jof6030143

Ejemplares similares