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Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1
Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of genes (FKS1 or FKS2) that encode the glucan s...
Autores principales: | Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558938/ https://www.ncbi.nlm.nih.gov/pubmed/32825653 http://dx.doi.org/10.3390/jof6030143 |
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