Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs

In this study, we systematically evaluated “bottom-up” physiologically based oral absorption modeling, focusing on free weak base drugs. The gastrointestinal unified theoretical framework (the GUT framework) was employed as a simple and transparent model. The oral absorption of poorly soluble free w...

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Detalles Bibliográficos
Autores principales: Matsumura, Naoya, Ono, Asami, Akiyama, Yoshiyuki, Fujita, Takuya, Sugano, Kiyohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558956/
https://www.ncbi.nlm.nih.gov/pubmed/32899235
http://dx.doi.org/10.3390/pharmaceutics12090844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558956/
https://www.ncbi.nlm.nih.gov/pubmed/32899235
http://dx.doi.org/10.3390/pharmaceutics12090844

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