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Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs

In this study, we systematically evaluated “bottom-up” physiologically based oral absorption modeling, focusing on free weak base drugs. The gastrointestinal unified theoretical framework (the GUT framework) was employed as a simple and transparent model. The oral absorption of poorly soluble free w...

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Detalles Bibliográficos
Autores principales:	Matsumura, Naoya, Ono, Asami, Akiyama, Yoshiyuki, Fujita, Takuya, Sugano, Kiyohiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558956/ https://www.ncbi.nlm.nih.gov/pubmed/32899235 http://dx.doi.org/10.3390/pharmaceutics12090844

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