Drug-induced cholestasis assay in primary hepatocytes

Drug-induced cholestasis (DIC) is a major cause of clinical failure of drug candidates. Numerous patients worldwide are affected when exposed to marketed drugs exhibiting a DIC signature. Prospective identification of DIC during early compound development remains challenging. Here we describe the op...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Brantegem, Pieter, Chatterjee, Sagnik, De Bruyn, Tom, Annaert, Pieter, Deferm, Neel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559231/
https://www.ncbi.nlm.nih.gov/pubmed/33088729
http://dx.doi.org/10.1016/j.mex.2020.101080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559231/
https://www.ncbi.nlm.nih.gov/pubmed/33088729
http://dx.doi.org/10.1016/j.mex.2020.101080

Ejemplares similares