Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice

Diabetic peripheral neuropathy (DPN) is a common diabetic complication and has yet no efficient medication. Here, we report that antispasmodic drug drofenine (Dfe) blocks Kv2.1 and ameliorates DPN-like pathology in diabetic mice. The underlying mechanisms are investigated against the DPN mice with i...

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Detalles Bibliográficos
Autores principales: Xu, Xiaoju, Xu, Xu, Hao, Yanping, Zhu, Xialin, Lu, Jian, Ouyang, Xingnan, Lu, Yin, Huang, Xi, Li, Yang, Wang, Jiaying, Shen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559245/
https://www.ncbi.nlm.nih.gov/pubmed/33089105
http://dx.doi.org/10.1016/j.isci.2020.101617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559245/
https://www.ncbi.nlm.nih.gov/pubmed/33089105
http://dx.doi.org/10.1016/j.isci.2020.101617

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