Cargando…
Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin
The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the ocular half-life in rabbits, however, the underlying molecular mechanisms and translational relevance rem...
Autores principales: | Hauri, Simon, Jakubiak, Paulina, Fueth, Matthias, Dengl, Stefan, Belli, Sara, Alvarez-Sánchez, Rubén, Caruso, Antonello |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559355/ https://www.ncbi.nlm.nih.gov/pubmed/32858986 http://dx.doi.org/10.3390/pharmaceutics12090810 |
Ejemplares similares
-
Are Ocular and Serum Half-Lives After Ranibizumab Intravitreal Injection Dependent on Dose?
por: van Donge, Tamara, et al.
Publicado: (2023) -
Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection?
por: Caruso, Antonello, et al.
Publicado: (2020) -
An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications
por: Kuhlmann, Matthias, et al.
Publicado: (2017) -
Extension of human GCSF serum half-life by the fusion of albumin binding domain
por: Nikravesh, Fatemeh Yadavar, et al.
Publicado: (2022) -
Author Response: Does the Fc Region Have a Role in the Ocular Half-Life After Intravitreal Injection?
por: Joo, Kwangsic, et al.
Publicado: (2020)