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Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model
This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were stored at 25 °C, 75% relative humidity for 1 week. Then, measur...
Autores principales: | Kosugi, Atsushi, Leong, Kok Hoong, Urata, Eri, Hayashi, Yoshihiro, Kumada, Shungo, Okada, Kotaro, Onuki, Yoshinori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559487/ https://www.ncbi.nlm.nih.gov/pubmed/32961856 http://dx.doi.org/10.3390/pharmaceutics12090886 |
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