SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy

Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes...

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Detalles Bibliográficos
Autores principales: Sharma, Sudha, Bhattarai, Susmita, Ara, Hosne, Sun, Grace, St Clair, Daret K., Bhuiyan, Md Shenuarin, Kevil, Christopher, Watts, Megan N., Dominic, Paari, Shimizu, Takahiko, McCarthy, Kevin J., Sun, Hong, Panchatcharam, Manikandan, Miriyala, Sumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559509/
https://www.ncbi.nlm.nih.gov/pubmed/33049519
http://dx.doi.org/10.1016/j.redox.2020.101740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559509/
https://www.ncbi.nlm.nih.gov/pubmed/33049519
http://dx.doi.org/10.1016/j.redox.2020.101740

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