Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet

OBJECTIVE: The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor that plays major roles in the central control of energy balance. Loss-of-function mutations of MC4R constitute the most common monogenic cause of early-onset extreme obesity in humans, whereas gain-of-function mutations ap...

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Detalles Bibliográficos
Autores principales: Rojo, Daniela, McCarthy, Clara, Raingo, Jesica, Rubinstein, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559519/
https://www.ncbi.nlm.nih.gov/pubmed/32916307
http://dx.doi.org/10.1016/j.molmet.2020.101077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559519/
https://www.ncbi.nlm.nih.gov/pubmed/32916307
http://dx.doi.org/10.1016/j.molmet.2020.101077

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