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In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration
Bone morphogenetic protein-2 (BMP-2) is a known key mediator of physiological bone regeneration and is clinically approved for selected musculoskeletal interventions. Yet, broad usage of this growth factor is impeded due to side effects that are majorly evoked by high dosages and burst release kinet...
Autores principales: | Berkmann, Julia C., Herrera Martin, Aaron X., Pontremoli, Carlotta, Zheng, Kai, Bucher, Christian H., Ellinghaus, Agnes, Boccaccini, Aldo R., Fiorilli, Sonia, Vitale Brovarone, Chiara, Duda, Georg N., Schmidt-Bleek, Katharina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559713/ https://www.ncbi.nlm.nih.gov/pubmed/32872353 http://dx.doi.org/10.3390/pharmaceutics12090823 |
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