TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

BACKGROUND: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting the PI3K pathway have been underwhelming and the development...

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Detalles Bibliográficos
Autores principales: Ruicci, Kara M., Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559997/
https://www.ncbi.nlm.nih.gov/pubmed/33059733
http://dx.doi.org/10.1186/s13046-020-01713-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559997/
https://www.ncbi.nlm.nih.gov/pubmed/33059733
http://dx.doi.org/10.1186/s13046-020-01713-9

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