Cargando…

TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

BACKGROUND: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting the PI3K pathway have been underwhelming and the development...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruicci, Kara M., Meens, Jalna, Plantinga, Paul, Stecho, William, Pinto, Nicole, Yoo, John, Fung, Kevin, MacNeil, Danielle, Mymryk, Joe S., Barrett, John W., Howlett, Christopher J., Boutros, Paul C., Ailles, Laurie, Nichols, Anthony C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559997/ https://www.ncbi.nlm.nih.gov/pubmed/33059733 http://dx.doi.org/10.1186/s13046-020-01713-9

Ejemplares similares

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
por: Ruicci, Kara M., et al.
Publicado: (2019)

Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models
por: Pinto, Nicole, et al.
Publicado: (2020)

Establishment and Use of Patient-Derived Xenograft Models for Drug Testing in Head and Neck Squamous Cell Carcinoma
por: Karamboulas, Christina, et al.
Publicado: (2020)

Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival
por: Mundi, Neil, et al.
Publicado: (2019)

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines
por: Ghasemi, Farhad, et al.
Publicado: (2018)

Introduction and expression of PIK3CA(E545K) in a papillary thyroid cancer BRAF(V600E) cell line leads to a dedifferentiated aggressive phenotype
por: Pinto, Nicole, et al.
Publicado: (2022)

Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models
por: Pinto, Nicole, et al.
Publicado: (2018)

Dose predictions for [(177)Lu]Lu-DOTA-panitumumab F(ab′)(2) in NRG mice with HNSCC patient-derived tumour xenografts based on [(64)Cu]Cu-DOTA-panitumumab F(ab′)(2) – implications for a PET theranostic strategy
por: Ku, Anthony, et al.
Publicado: (2021)

Does HPV Subtype Predict Outcomes in Head and Neck Cancers?
por: Ziai, Hedyeh, et al.
Publicado: (2021)

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer
por: Ghasemi, Farhad, et al.
Publicado: (2017)

Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis
por: Gameiro, Steven F., et al.
Publicado: (2021)

Detection of Circulating Tumor DNA in Patients with Thyroid Nodules
por: Patel, Krupal B., et al.
Publicado: (2021)

Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma
por: Gedye, Craig, et al.
Publicado: (2016)

High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells
por: Gameiro, Steven F., et al.
Publicado: (2019)

A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases
por: Nichols, Anthony C., et al.
Publicado: (2013)

Establishment of four head and neck squamous cell carcinoma cell lines: importance of reference DNA for accurate genomic characterisation
por: Patel, K B, et al.
Publicado: (2023)

Viral Retasking of hBre1/RNF20 to Recruit hPaf1 for Transcriptional Activation
por: Fonseca, Gregory J., et al.
Publicado: (2013)

Genomically Driven Precision Medicine to Improve Outcomes in Anaplastic Thyroid Cancer
por: Pinto, Nicole, et al.
Publicado: (2014)

Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin
por: Gameiro, Steven F., et al.
Publicado: (2017)

Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection
por: Gameiro, Steven F., et al.
Publicado: (2017)

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21
por: Hussain, Ali, et al.
Publicado: (2020)

Analysis of the TCGA Dataset Reveals that Subsites of Laryngeal Squamous Cell Carcinoma Are Molecularly Distinct
por: Sorgini, Alana, et al.
Publicado: (2020)

The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
por: Elliott, Bruce E, et al.
Publicado: (2005)

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification
por: Zeng, Peter Y.F., et al.
Publicado: (2022)

Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome
por: Tessier, Tanner M., et al.
Publicado: (2020)

TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting
por: Peeters, Marlies J. W., et al.
Publicado: (2019)

The HPV Induced Cancer Resource (THInCR): a Suite of Tools for Investigating HPV-Dependent Human Carcinogenesis
por: Salnikov, Mikhail, et al.
Publicado: (2022)

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities
por: Lew, Erin D, et al.
Publicado: (2014)

3p Arm Loss and Survival in Head and Neck Cancer: An Analysis of TCGA Dataset
por: Kim, Hugh Andrew Jinwook, et al.
Publicado: (2021)

Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy
por: Gameiro, Steven F., et al.
Publicado: (2018)

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing
por: Nichols, Anthony C., et al.
Publicado: (2012)

Diversification of TAM receptor function
por: Zagórska, Anna, et al.
Publicado: (2014)

Targeting the TAM Receptors in Leukemia
por: Huey, Madeline G., et al.
Publicado: (2016)

DICERing macrophages for reprogramming TAMs
por: Squadrito, Mario Leonardo, et al.
Publicado: (2016)

TAM receptors in cardiovascular disease
por: McShane, Lucy, et al.
Publicado: (2019)

TAM Signaling in the Nervous System
por: Burstyn-Cohen, Tal, et al.
Publicado: (2021)

Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
por: Chander, Harish, et al.
Publicado: (2014)

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module
por: Selkrig, Joel, et al.
Publicado: (2015)

Evolution of the Translocation and Assembly Module (TAM)
por: Heinz, Eva, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_scafd7l8fvfhf9t7gaoeni73jm