Environmentally Friendly Fluoroquinolone Derivatives with Lower Plasma Protein Binding Rate Designed Using 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation

Comparative molecular similarity index analysis (CoMSIA) was used to establish a three-dimensional quantitative structure–activity relationship (3D-QSAR) model with structural parameters of quinolones as the independent variables and plasma protein binding rate (logf(b)) as the dependent variable to...

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Detalles Bibliográficos
Autores principales: Hou, Yilin, Zhao, Yuanyuan, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560044/
https://www.ncbi.nlm.nih.gov/pubmed/32932916
http://dx.doi.org/10.3390/ijerph17186626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560044/
https://www.ncbi.nlm.nih.gov/pubmed/32932916
http://dx.doi.org/10.3390/ijerph17186626

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