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Environmentally Friendly Fluoroquinolone Derivatives with Lower Plasma Protein Binding Rate Designed Using 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation

Comparative molecular similarity index analysis (CoMSIA) was used to establish a three-dimensional quantitative structure–activity relationship (3D-QSAR) model with structural parameters of quinolones as the independent variables and plasma protein binding rate (logf(b)) as the dependent variable to...

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Detalles Bibliográficos
Autores principales:	Hou, Yilin, Zhao, Yuanyuan, Li, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560044/ https://www.ncbi.nlm.nih.gov/pubmed/32932916 http://dx.doi.org/10.3390/ijerph17186626

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