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γ‐Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
Sequence variants of the microglial expressed TREM2 (triggering receptor expressed on myeloid cells 2) are a major risk factor for late onset Alzheimer's disease. TREM2 requires a stable interaction with DAP12 in the membrane to initiate signaling, which is terminated by TREM2 ectodomain sheddi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560206/ https://www.ncbi.nlm.nih.gov/pubmed/32830336 http://dx.doi.org/10.15252/embj.2019104247 |