Cargando…

Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA

Detection of viral DNA by cyclic GMP‐AMP synthase (cGAS) is a first line of defence leading to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN, we hypothesised that an intact capsid physically cloaks viral DNA from cGAS. To test this, we generated defec...

Descripción completa

Detalles Bibliográficos
Autores principales: Sumner, Rebecca P, Harrison, Lauren, Touizer, Emma, Peacock, Thomas P, Spencer, Matthew, Zuliani‐Alvarez, Lorena, Towers, Greg J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560218/
https://www.ncbi.nlm.nih.gov/pubmed/32852081
http://dx.doi.org/10.15252/embj.2019103958