Cargando…

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still unknown. Cellular cholesterol levels are regulated through crosstalk between the plasma membrane (PM), where most ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Montesinos, Jorge, Pera, Marta, Larrea, Delfina, Guardia‐Laguarta, Cristina, Agrawal, Rishi R, Velasco, Kevin R, Yun, Taekyung D, Stavrovskaya, Irina G, Xu, Yimeng, Koo, So Yeon, Snead, Amanda M, Sproul, Andrew A, Area‐Gomez, Estela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560219/ https://www.ncbi.nlm.nih.gov/pubmed/32865299 http://dx.doi.org/10.15252/embj.2019103791

Ejemplares similares

Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
por: Pera, Marta, et al.
Publicado: (2017)

MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics
por: Larrea, Delfina, et al.
Publicado: (2019)

Novel subcellular localization for α-synuclein: possible functional consequences
por: Guardia-Laguarta, Cristina, et al.
Publicado: (2015)

Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury
por: Agrawal, Rishi R., et al.
Publicado: (2022)

ApoE4 upregulates the activity of mitochondria‐associated ER membranes
por: Tambini, Marc D, et al.
Publicado: (2015)

Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease
por: Chen, Jacinda, et al.
Publicado: (2023)

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
por: Area-Gomez, Estela, et al.
Publicado: (2020)

Lipid level alteration in human and cellular models of alpha synuclein mutations
por: Avisar, Hila, et al.
Publicado: (2022)

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
por: Pera, Marta, et al.
Publicado: (2012)

Ethanol Induces Extracellular Vesicle Secretion by Altering Lipid Metabolism through the Mitochondria-Associated ER Membranes and Sphingomyelinases
por: Ibáñez, Francesc, et al.
Publicado: (2021)

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
por: Area-Gomez, Estela, et al.
Publicado: (2012)

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
por: Arenas, Fabian, et al.
Publicado: (2017)

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
por: Wang, Xin, et al.
Publicado: (2017)

Surface Trafficking of APP and BACE in Live Cells
por: Bauereiss, Anna, et al.
Publicado: (2015)

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
por: Zhang, Xiaojie, et al.
Publicado: (2013)

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
por: Lyu, Junfang, et al.
Publicado: (2019)

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection
por: Semini, Geo, et al.
Publicado: (2017)

Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis
por: Boutry, Maxime, et al.
Publicado: (2019)

Editorial: Energy Requirements in Membrane Trafficking
por: Guardia, Carlos M., et al.
Publicado: (2021)

Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
por: Area-Gomez, Estela, et al.
Publicado: (2021)

Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations
por: Li, Cheng-Dong, et al.
Publicado: (2022)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

Human Adenoviruses, Cholesterol Trafficking, and NF-κB Signaling
por: Cianciola, Nicholas L., et al.
Publicado: (2018)

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
por: de la Roche, Marianne, et al.
Publicado: (2018)

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
por: Sun, Jichao, et al.
Publicado: (2019)

Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
por: Sobo, Komla, et al.
Publicado: (2007)

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
por: Lyu, Junfang, et al.
Publicado: (2018)

Investigating the Role of Cholesterol and Lipid Trafficking in Mitotane Resistance in Adrenocortical Carcinoma
por: Warde, Kate, et al.
Publicado: (2021)

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease
por: Area-Gomez, Estela, et al.
Publicado: (2018)

DISC1 regulates trafficking and processing of APP and Aβ generation
por: Shahani, Neelam, et al.
Publicado: (2014)

Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization
por: Langness, Vanessa F., et al.
Publicado: (2021)

Glycolipid Trafficking in Drosophila Undergoes Pathway Switching in Response to Aberrant Cholesterol Levels
por: Hortsch, Ralf, et al.
Publicado: (2010)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
por: McCauliff, Leslie A, et al.
Publicado: (2019)

ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking
por: Nakato, Mitsuhiro, et al.
Publicado: (2020)

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking
por: Palladino, Elisa N. D., et al.
Publicado: (2022)

FE65 as a link between VLDLR and APP to regulate their trafficking and processing
por: Dumanis, Sonya B, et al.
Publicado: (2012)

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival
por: Zhang, Yun-wu, et al.
Publicado: (2013)

Designing an Informative App for Neurorehabilitation: A Feasibility and Satisfaction Study by Physiotherapists
por: Sánchez-Rodríguez, María Teresa, et al.
Publicado: (2023)

Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity
por: Schilling, Sandra, et al.
Publicado: (2023)

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function
por: Reverter, Meritxell, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4oe0fn9kpv1rs0lh98rjhfh33f