Differential expression of predisposing HLA-DQ2.5 alleles in DR5/DR7 celiac disease patients affects the pathological immune response to gluten

The DR5-DQ7/DR7-DQ2 genotype is very frequent among patients affected by celiac disease (CD), in Europe. This genotype, associated to high risk of CD, carries the HLA-DQA1*05 and HLA-DQB1*02 predisposing alleles, in trans configuration. The alleles encode the DQ2.5 heterodimer responsible of gluten...

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Detalles Bibliográficos
Autores principales: Pisapia, Laura, Picascia, Stefania, Farina, Federica, Barba, Pasquale, Gianfrani, Carmen, Del Pozzo, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560598/
https://www.ncbi.nlm.nih.gov/pubmed/33057065
http://dx.doi.org/10.1038/s41598-020-73907-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560598/
https://www.ncbi.nlm.nih.gov/pubmed/33057065
http://dx.doi.org/10.1038/s41598-020-73907-2

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