The Janus-like role of proline metabolism in cancer

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes, which catalyze the last step i...

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Detalles Bibliográficos
Autores principales: Burke, Lynsey, Guterman, Inna, Palacios Gallego, Raquel, Britton, Robert G., Burschowsky, Daniel, Tufarelli, Cristina, Rufini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560826/
https://www.ncbi.nlm.nih.gov/pubmed/33083024
http://dx.doi.org/10.1038/s41420-020-00341-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560826/
https://www.ncbi.nlm.nih.gov/pubmed/33083024
http://dx.doi.org/10.1038/s41420-020-00341-8

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