Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

BACKGROUND: Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and treatment strategies are not established. OBJECTIV...

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Detalles Bibliográficos
Autores principales: Clayton, Zachary S., Brunt, Vienna E., Hutton, David A., VanDongen, Nicholas S., D’Alessandro, Angelo, Reisz, Julie A., Ziemba, Brian P., Seals, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561020/
https://www.ncbi.nlm.nih.gov/pubmed/33073250
http://dx.doi.org/10.1016/j.jaccao.2020.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561020/
https://www.ncbi.nlm.nih.gov/pubmed/33073250
http://dx.doi.org/10.1016/j.jaccao.2020.06.010

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