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Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

BACKGROUND: Doxorubicin (DOXO) chemotherapy increases risk for cardiovascular disease in part by inducing endothelial dysfunction in conduit arteries. However, the mechanisms mediating DOXO-associated endothelial dysfunction in (intact) arteries and treatment strategies are not established. OBJECTIV...

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Detalles Bibliográficos
Autores principales:	Clayton, Zachary S., Brunt, Vienna E., Hutton, David A., VanDongen, Nicholas S., D’Alessandro, Angelo, Reisz, Julie A., Ziemba, Brian P., Seals, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561020/ https://www.ncbi.nlm.nih.gov/pubmed/33073250 http://dx.doi.org/10.1016/j.jaccao.2020.06.010

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