Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

Angelman syndrome is a complex neurodevelopmental disorder characterized by delayed development, intellectual disability, speech impairment, and ataxia. It results from the loss of UBE3A protein, an E3 ubiquitin ligase, in neurons of the brain. Despite the dynamic spatiotemporal expression of UBE3A...

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Detalles Bibliográficos
Autores principales: Sen, Dilara, Voulgaropoulos, Alexis, Drobna, Zuzana, Keung, Albert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561513/
https://www.ncbi.nlm.nih.gov/pubmed/32916124
http://dx.doi.org/10.1016/j.stemcr.2020.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561513/
https://www.ncbi.nlm.nih.gov/pubmed/32916124
http://dx.doi.org/10.1016/j.stemcr.2020.08.006

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