Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

Suspended human hepatocytes (SHH) have long been used in assessing hepatic drug uptake, while plated human hepatocytes in short-term monolayer culture (PHH) have gained use in recent years. This study aimed to cross-evaluate SHH and PHH in measuring the hepatic uptake mediated by organic anion trans...

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Detalles Bibliográficos
Autores principales: Lee, Wooin, Koyama, Satoshi, Morita, Kiyoe, Kiriake, Aya, Kikuchi, Ryota, Chu, Xiaoyan, Lee, Nora, Scialis, Renato J., Shen, Hong, Kimoto, Emi, Tremaine, Larry, Ishiguro, Naoki, Lotz, Ralf, Maeda, Kazuya, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561564/
https://www.ncbi.nlm.nih.gov/pubmed/33063163
http://dx.doi.org/10.1208/s12248-020-00512-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561564/
https://www.ncbi.nlm.nih.gov/pubmed/33063163
http://dx.doi.org/10.1208/s12248-020-00512-6

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