Distribution of disease-causing germline mutations in coiled-coils implies an important role of their N-terminal region

Next-generation sequencing resulted in the identification of a huge number of naturally occurring variations in human proteins. The correct interpretation of the functional effects of these variations necessitates the understanding of how they modulate protein structure. Coiled-coils are α-helical s...

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Detalles Bibliográficos
Autores principales: Kalman, Zsofia E., Mészáros, Bálint, Gáspári, Zoltán, Dobson, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562717/
https://www.ncbi.nlm.nih.gov/pubmed/33060664
http://dx.doi.org/10.1038/s41598-020-74354-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562717/
https://www.ncbi.nlm.nih.gov/pubmed/33060664
http://dx.doi.org/10.1038/s41598-020-74354-9

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