DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

During neuronal differentiation, the transcriptional profile and the epigenetic context of neural committed cells is subject to significant rearrangements, but a systematic quantification of global histone modification changes is still missing. Here, we show that H3K79me2 increases and H3K27ac decre...

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Detalles Bibliográficos
Autores principales: Ferrari, Francesco, Arrigoni, Laura, Franz, Henriette, Izzo, Annalisa, Butenko, Ludmila, Trompouki, Eirini, Vogel, Tanja, Manke, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562744/
https://www.ncbi.nlm.nih.gov/pubmed/33060580
http://dx.doi.org/10.1038/s41467-020-19001-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562744/
https://www.ncbi.nlm.nih.gov/pubmed/33060580
http://dx.doi.org/10.1038/s41467-020-19001-7

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