Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor

Methadone is a synthetic opioid agonist with notoriously unique properties, such as lower abuse liability and induced relief of withdrawal symptoms and drug cravings, despite acting on the same opioid receptors triggered by classic opioids—in particular the µ-opioid receptor (MOR). Its distinct phar...

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Detalles Bibliográficos
Autores principales: Kapoor, Abhijeet, Provasi, Davide, Filizola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Special Section on 50 Years of Opioid Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562981/
https://www.ncbi.nlm.nih.gov/pubmed/32680919
http://dx.doi.org/10.1124/mol.119.119339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562981/
https://www.ncbi.nlm.nih.gov/pubmed/32680919
http://dx.doi.org/10.1124/mol.119.119339

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