Cargando…

Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor

Methadone is a synthetic opioid agonist with notoriously unique properties, such as lower abuse liability and induced relief of withdrawal symptoms and drug cravings, despite acting on the same opioid receptors triggered by classic opioids—in particular the µ-opioid receptor (MOR). Its distinct phar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kapoor, Abhijeet, Provasi, Davide, Filizola, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:	Special Section on 50 Years of Opioid Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562981/ https://www.ncbi.nlm.nih.gov/pubmed/32680919 http://dx.doi.org/10.1124/mol.119.119339

Ejemplares similares

Recent Progress in Opioid Research from an Electrophysiological Perspective
por: Birdsong, William T., et al.
Publicado: (2020)

Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms
por: Eacret, D., et al.
Publicado: (2020)

Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity
por: Kapoor, Abhijeet, et al.
Publicado: (2017)

Using machine learning to advance disparities research: Subgroup analyses of access to opioid treatment
por: Kong, Yinfei, et al.
Publicado: (2021)

Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model
por: Marino, Kristen A., et al.
Publicado: (2016)

Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
por: Webster, Lynn, et al.
Publicado: (2016)

A retrospective chart review of opioid represcribing following nonfatal overdose at a Veterans Affairs hospital
por: Boyle, Julia, et al.
Publicado: (2018)

Implementation and results of a symptom-triggered opioid withdrawal protocol at a Veterans Affairs medical center
por: Koch, Jessa, et al.
Publicado: (2018)

Evaluation of buprenorphine/naloxone dose and use of sedating supportive medication on treatment outcomes in veterans with opioid use disorder
por: Kapuganti, Amber, et al.
Publicado: (2018)

Are Prescription Opioids Driving the Opioid Crisis? Assumptions vs Facts
por: Rose, Mark Edmund
Publicado: (2018)

Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis
por: Hu, Xiaohu, et al.
Publicado: (2019)

Active control of properties of concrete: a (p)review
por: De Schutter, Geert, et al.
Publicado: (2018)

How models can make a difference for a sustainable future of the building industry
por: van Breugel, Klaas
Publicado: (2018)

Incidence of Dermabond hypersensitivity post laparoscopy in a PAG population prior to and after onset of the SARS-CoV-2 Pandemic
por: Hamouie, Angie, et al.
Publicado: (2022)

Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations
por: Meral, Derya, et al.
Publicado: (2018)

Lessons from Free Energy Simulations of δ-Opioid Receptor Homodimers Involving the Fourth Transmembrane Helix
por: Provasi, Davide, et al.
Publicado: (2010)

Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area
por: Lowe, J D, et al.
Publicado: (2015)

Consensus Recommendations on Initiating Prescription Therapies for Opioid‐Induced Constipation
por: Argoff, Charles E., et al.
Publicado: (2015)

Discrepancies Between Perceived Benefit of Opioids and Self-Reported Patient Outcomes
por: Goesling, Jenna, et al.
Publicado: (2018)

Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone
por: Webster, Lynn, et al.
Publicado: (2018)

Laxatives Do Not Improve Symptoms of Opioid-Induced Constipation: Results of a Patient Survey
por: Emmanuel, Anton, et al.
Publicado: (2017)

Rational Urine Drug Monitoring in Patients Receiving Opioids for Chronic Pain: Consensus Recommendations
por: Argoff, Charles E, et al.
Publicado: (2018)

Effect of Preoperative Opioid Use on Adverse Outcomes, Medical Spending, and Persistent Opioid Use Following Elective Total Joint Arthroplasty in the United States: A Large Retrospective Cohort Study of Administrative Claims Data
por: Blevins Peratikos, Meridith, et al.
Publicado: (2020)

Relative Abuse of Crush-Resistant Prescription Opioid Tablets via Alternative Oral Modes of Administration
por: Butler, Stephen F, et al.
Publicado: (2018)

ER/LA Opioid Analgesics REMS: Overview of Ongoing Assessments of Its Progress and Its Impact on Health Outcomes
por: Cepeda, M. Soledad, et al.
Publicado: (2017)

A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid
por: Shaparin, Naum, et al.
Publicado: (2017)

Preferred Supramolecular Organization and Dimer Interfaces of Opioid Receptors from Simulated Self-Association
por: Provasi, Davide, et al.
Publicado: (2015)

Changes in Mortality Involving Extended-Release and Long-Acting Opioids After Implementation of a Risk Evaluation and Mitigation Strategy
por: Black, Joshua C, et al.
Publicado: (2020)

Oral Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users
por: Harris, Stephen C., et al.
Publicado: (2017)

Risk Factors for Serious Prescription Opioid-Induced Respiratory Depression or Overdose: Comparison of Commercially Insured and Veterans Health Affairs Populations
por: Nadpara, Pramit A, et al.
Publicado: (2018)

Record Linkage Approaches Using Prescription Drug Monitoring Program and Mortality Data for Public Health Analyses and Epidemiologic Studies
por: Nechuta, Sarah, et al.
Publicado: (2020)

The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies
por: Meier, Isabell M., et al.
Publicado: (2021)

Abuse Potential with Oral Route of Administration of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Darwish, Mona, et al.
Publicado: (2017)

Evaluation of the Relative Intranasal Abuse Potential of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Bond, Mary, et al.
Publicado: (2018)

New and Emerging Opioid Overdose Risk Factors
por: Foglia, Ralph, et al.
Publicado: (2021)

Validation of a Screening Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose in a US Commercial Health Plan Claims Database
por: Zedler, Barbara K, et al.
Publicado: (2018)

Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial
por: Webster, Lynn R., et al.
Publicado: (2017)

Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain
por: Henningfield, Jack E, et al.
Publicado: (2020)

Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users
por: Setnik, Beatrice, et al.
Publicado: (2017)

Assessing the Relative Stability of Dimer Interfaces in G Protein-Coupled Receptors
por: Johnston, Jennifer M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1prn5krb7b6g80ggp8t3e6a3q0