Fibrotic Changes and Endothelial-to-Mesenchymal Transition Promoted by VEGFR2 Antagonism Alter the Therapeutic Effects of VEGFA Pathway Blockage in a Mouse Model of Choroidal Neovascularization

Many patients with wet age-related macular degeneration do not respond well to anti- vascular endothelial growth factor A (VEGFA) therapy for choroidal neovascularization (CNV), and the efficacy of anti-VEGFA decreases over time. We investigated the hypothesis that fibrotic changes, in particular vi...

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Detalles Bibliográficos
Autores principales: Rossato, Franco Aparecido, Su, Yu, Mackey, Ashley, Ng, Yin Shan Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563259/
https://www.ncbi.nlm.nih.gov/pubmed/32917003
http://dx.doi.org/10.3390/cells9092057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563259/
https://www.ncbi.nlm.nih.gov/pubmed/32917003
http://dx.doi.org/10.3390/cells9092057

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