Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

SIMPLE SUMMARY: Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options. The aim of the current study is to evaluate the role of Furin, a proprotein convertase involved in the activation of wide range of protein precursors in TNBC progression. The generat...

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Detalles Bibliográficos
Autores principales: He, Zongsheng, Khatib, Abdel-Majid, Creemers, John W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563341/
https://www.ncbi.nlm.nih.gov/pubmed/32962246
http://dx.doi.org/10.3390/cancers12092686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563341/
https://www.ncbi.nlm.nih.gov/pubmed/32962246
http://dx.doi.org/10.3390/cancers12092686

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