Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer

SIMPLE SUMMARY: Tumor suppressing effect of metformin has been reported, and one of mechanism of this effect is suppression of cancer stem cells (CSCs). However, detailed mechanism of metformin-induced CSC-inhibitory effect has not been known. We demonstrated that the CSC-suppressive effect of metfo...

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Detalles Bibliográficos
Autores principales: Seo, Yoojeong, Kim, Janghyun, Park, Soo Jung, Park, Jae Jun, Cheon, Jae Hee, Kim, Won Ho, Kim, Tae Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563617/
https://www.ncbi.nlm.nih.gov/pubmed/32911743
http://dx.doi.org/10.3390/cancers12092554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563617/
https://www.ncbi.nlm.nih.gov/pubmed/32911743
http://dx.doi.org/10.3390/cancers12092554

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