Cargando…

Akt+ IKKα/β+ Rab5+ Signalosome Mediate the Endosomal Recruitment of Sec61 and Contribute to Cross-Presentation in Bone Marrow Precursor Cells

Cross-presentation in dendritic cells (DC) requires the endosomal relocations of internalized antigens and the endoplasmic reticulum protein Sec61. Despite the fact that endotoxin-containing pathogen and endotoxin-free antigen have different effects on protein kinase B (Akt) and I-kappa B Kinase α/β...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Dan Dan, Hu, Chun Fang, You, Xiang, Lu, Nan Nan, Gao, Feng Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563657/ https://www.ncbi.nlm.nih.gov/pubmed/32957586 http://dx.doi.org/10.3390/vaccines8030539

Ejemplares similares

PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation
por: You, Xiang, et al.
Publicado: (2018)

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7
por: Rojas, Raul, et al.
Publicado: (2008)

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier
por: Haßdenteufel, Sarah, et al.
Publicado: (2018)

Crosstalk between the NF-κB activating IKK-complex and the CSN signalosome
por: Orel, Lukas, et al.
Publicado: (2010)

FgRab5 and FgRab7 are essential for endosomes biogenesis and non-redundantly recruit the retromer complex to the endosomes in Fusarium graminearum
por: Abubakar, Yakubu Saddeeq, et al.
Publicado: (2021)

Loopy Sec61 mutants
por: LeBrasseur, Nicole
Publicado: (2005)

Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
por: Sicking, Mark, et al.
Publicado: (2021)

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
por: Itskanov, Samuel, et al.
Publicado: (2021)

Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth
por: Kobayashi, Hotaka, et al.
Publicado: (2014)

Sec61 in antigen cross-presentation
por: Zehner, Matthias, et al.
Publicado: (2015)

Role of the Cytoplasmic Segments of Sec61α in the Ribosome-Binding and Translocation-Promoting Activities of the Sec61 Complex
por: Raden, David, et al.
Publicado: (2000)

How does Sec63 affect the conformation of Sec61 in yeast?
por: Bhadra, Pratiti, et al.
Publicado: (2021)

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome
por: Goto-Silva, Livia, et al.
Publicado: (2019)

Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
por: Linxweiler, Maximilian, et al.
Publicado: (2017)

Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes
por: Liu, Ou, et al.
Publicado: (2015)

Rab22A recruits BLOC‐1 and BLOC‐2 to promote the biogenesis of recycling endosomes
por: Shakya, Saurabh, et al.
Publicado: (2018)

Sec61β, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.
por: Kelkar, Anshuman, et al.
Publicado: (2009)

Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation
por: Wang, Yan Yan, et al.
Publicado: (2016)

AKT2 deficiency impairs formation of the BCR signalosome
por: Du, Zuochen, et al.
Publicado: (2020)

Structure of the native Sec61 protein-conducting channel
por: Pfeffer, Stefan, et al.
Publicado: (2015)

MoSec61β, the beta subunit of Sec61, is involved in fungal development and pathogenicity, plant immunity, and ER-phagy in Magnaporthe oryzae
por: Wei, Yun-Yun, et al.
Publicado: (2020)

Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast
por: Ortiz, Darinel, et al.
Publicado: (2002)

Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes
por: Bean, Bjorn D. M., et al.
Publicado: (2015)

Sec61p Is Required for ERAD-L: GENETIC DISSECTION OF THE TRANSLOCATION AND ERAD-L FUNCTIONS OF Sec61P USING NOVEL DERIVATIVES OF CPY
por: Willer, Martin, et al.
Publicado: (2008)

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation
por: Barbieri, Guido, et al.
Publicado: (2023)

Intrinsic tethering activity of endosomal Rab proteins
por: Lo, Sheng-Ying, et al.
Publicado: (2011)

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation
por: Jadhav, Bhalchandra, et al.
Publicado: (2015)

Mycolactone subverts immunity by selectively blocking the Sec61 translocon
por: Baron, Ludivine, et al.
Publicado: (2016)

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases
por: Lang, Sven, et al.
Publicado: (2017)

The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
por: Domenger, Antoine, et al.
Publicado: (2022)

The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3
por: John Peter, Arun T., et al.
Publicado: (2013)

TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis
por: Yu, Shiyan, et al.
Publicado: (2014)

A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase
por: Pool, Martin R.
Publicado: (2009)

Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
por: Lund, Viktor Karlovich, et al.
Publicado: (2018)

RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans
por: Zhang, Donglei, et al.
Publicado: (2016)

Endosomal Rab cycles regulate Parkin-mediated mitophagy
por: Yamano, Koji, et al.
Publicado: (2018)

Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB
por: Escrevente, Cristina, et al.
Publicado: (2021)

Cholera Toxin Is Exported from Microsomes by the Sec61p Complex
por: Schmitz, Anton, et al.
Publicado: (2000)

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
por: Zong, Guanghui, et al.
Publicado: (2019)

Signal peptide mimicry primes Sec61 for client-selective inhibition
por: Rehan, Shahid, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sbgd9vjl8ht031v7u101bq56q2