Lipid Modulation in the Formation of β-Sheet Structures. Implications for De Novo Design of Human Islet Amyloid Polypeptide and the Impact on β-Cell Homeostasis

Human islet amyloid polypeptide (hIAPP) corresponds to a 37-residue hormone present in insulin granules that maintains a high propensity to form β-sheet structures during co-secretion with insulin. Previously, employing a biomimetic approach, we proposed a panel of optimized IAPP sequences with only...

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Detalles Bibliográficos
Autores principales: Martínez-Navarro, Israel, Díaz-Molina, Raúl, Pulido-Capiz, Angel, Mas-Oliva, Jaime, Luna-Reyes, Ismael, Rodríguez-Velázquez, Eustolia, Rivero, Ignacio A., Ramos-Ibarra, Marco A., Alatorre-Meda, Manuel, García-González, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563882/
https://www.ncbi.nlm.nih.gov/pubmed/32824918
http://dx.doi.org/10.3390/biom10091201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563882/
https://www.ncbi.nlm.nih.gov/pubmed/32824918
http://dx.doi.org/10.3390/biom10091201

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